Therapeutic advances in neurootology.

About the impact of modern knowledge, science, and medicine on neurootology.

On the one hundredth birthday of Dr. Juan Manuel Tato, Buenos Aires, Argentina. Pioneer in advancing otorhinolaryngology into modern neurootology.

AearlY as 1969, I met Dr. Juan Manuel Tato, of Buenos Aires , Argentina, during his visit to the University of Wiirzburg, Germany where, in 1864, Dr. von Troeltsch had created the specialty of otology for the first time in history. Dr. Tato appeared as a true Spanish gentleman: polite , charming, well educated, and experienced in the ultimate stage of development of ear surgery. At that time, h...

Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer patients is their inability to discriminate between malignant and normal tissues. This in tu...

Medicine-based evidence: reverse translational ear research recommendations.

Presented here is a first-person account of the evolution of the practice of surgical neurootology to that of medical neurootology shaped mainly by results of treatment directed at underlying otosclerosis-like lesions of the otic capsule and metabolic factors. With new technologies and rapidly evolving concepts, the changing treatment algorithms did not remain constant to provide the usual evid...

The current status and future of theranostic Copper-64 radiopharmaceuticals

Copper-64 was produced in large scales and high specific activities in late 1990s’ using compact cyclotrons based by 64Ni(p,n)64Cu reaction and many radiopharmaceuticals developed since then by various groups based on interesting physicochemical and nuclear properties of the radionuclide. The unique emission of beta particles as well as positron particles offers a spectacu...